Scott Barman, PhD

Research Interest, Education & Publications

photo of Scott A. Barman, PhD

Scott A. Barman, PhD

  • Professor
  • Vice Chair for Education
  • Pharmacology & Toxicology

706-721-6352
Research & Education Building, CB 3626

Office phone icon: 706-721-6352
Lab phone icon: 706-721-7663

 

Members of the Lab

Louise Meadows

  • Senior Research Associate

Tiranda Plummer

  • Research Assistant

RESEARCH INTEREST

My laboratory is dedicated to investigating Galectin-3 (Gal-3) and PDZ-binding kinase (PBK) inhibition as potential therapeutic targets for pulmonary vascular disease by investigating the role of Gal-3 and PBK signaling in pulmonary vascular remodeling and fibrosis in PAH using an integrated approach of multiple animal models of PAH, cellular studies, pharmacological and genetic approaches (including KO rat models), as well as in vivo and in vitro measurements of pulmonary arterial and right ventricular function.

EDUCATION & POST-DOCTORAL TRAINING

BS                                       Muhlenberg College, Allentown, Pennsylvania
PhD                                    University of North Dakota, Grand Forks, ND
Postdoctoral Training      University of South Alabama, Mobile, Alabama

ACADEMIC APPOINTMENTS

Professor (tenured), Department of Pharmacology and Toxicology, Medical College of Georgia at 麻豆官网首页入口

Vice Chair of Education, Department of Pharmacology and Toxicology, Medical College of Georgia at 麻豆官网首页入口

Assistant Dean of Admissions, Medical College of Georgia at 麻豆官网首页入口

EDITORIAL BOARDS

Editorial Board Member, The Open Nitric Oxide Journal

GRANT REVIEW PANELS

Respiratory Integrative Biology and Translational Research (RIBT) Study Section 鈥� Standing Member

HONORS

Dean's List, Muhlenberg College

Graduate Research Assistantship, Department of Physiology, University of North Dakota

Graduate Research Assistantship, Department of Physiology, University of North Dakota North Dakota State Board of Higher Education Scholarship

Graduate Student Award for Outstanding Scientific Research-Sigma Xi Research Society, University of North Dakota Chapter

Parker B. Francis Fellowship

American Heart Association Fellowship 

NRSA Award

Outstanding Young Faculty Member Award (Basic Sciences) - Medical College of Georgia

Department of Pharmacology & Toxicology Teaching Award, Medical College of Georgia

Outstanding Leadership and Service Award 鈥� General Faculty Assembly, Medical Coll. of Georgia

School of Graduate Studies Distinguished Service Award, Medical College of Georgia

Outstanding Service Award 鈥� Co-Parliamentarian of Academic Council, Medical Coll. of Georgia

Fellow of American Heart Association (FAHA)

Travel Award 鈥� Pittsburgh International Lung Conference

CONTRIBUTIONS TO SCIENCE

Barman SA, Chen F, Su Y, Dimitropoulou C, Wang Y, Catravas JD, Han W, Orfi L, Szantai-Kis C, Keri G, Szabadkai I, Barabutis N, Rafikova O, Rafikov R, Black SM, Jonigk D, Giannis A, Asmis R, Stepp DW, Ramesh G, Fulton DJ.  NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling. Arterioscler Thromb Vasc Biol 2014 Aug;34(8):1704-15. doi: 10.1161/ATVBAHA.114.303848. PMID: 24947524

Chen F, LiX, Haigh H; Zhou, J; Stepp D, Weintraub N, Barman S, and Fulton D. Inhibition of Histone Deacetylase Reduces Transcription of NADPH Oxidases and ROS production and Ameliorates Pulmonary Arterial Hypertension. Free Rad Biol Med 2016 Oct;99:167-178 PMID: 27498117

Barman SA, and Fulton D. Adventitial Fibroblast Nox4 Expression and ROS Signaling in Pulmonary Arterial Hypertension. Adv Exp Med Biol 967:1-11, 2017. PMID: 29047077

Fulton DJR, Li X, Bordan Z, Haigh S, Bentley A, Chen F, Barman SA. Reactive Oxygen and Nitrogen Species in the Development of Pulmonary Hypertension. Antioxidants (Basel) 6(3), 2017. PMID: 28684719

Barman SA, Chen F, Li X, Haigh S, Stepp DW, Kondrikov D, Bordan Z, Traber P, Jonigk D, Su Y and Fulton DJR. Galectin-3 Promotes Vascular Remodeling and Contributes to Pulmonary Arterial Hypertension Am J Resp Crit Care Med 1; 197(11):1488-1492, 2018. PMID: 29365276

Barman SA, Li X, Haigh S, Kondrikov D, Mahboubi K, Bordan Z, Stepp DW, Zhou J, Wang Y, Weintraub DS, Traber P, Snider W, Jonigk D, Sullivan J, Crislip 骋搁赂 Butcher JT, Thompson J, Su Y, Chen F, and Fulton DJR. Galectin-3 is Expressed in Vascular Smooth Muscle Cells and Promotes Pulmonary Hypertension through changes in Proliferation, Apoptosis and Fibrosis.  Am J Physiol - Lung Cell Physiol 316: L784-797, 2019. PMID: 30724100

Fulton DJR, Li X, Bordan Z Wang Y, Mahboubi K, Rudic RD, Haigh S, Chen F, and Barman SA. Galectin-3: A Harbinger of Reactive Oxygen Species, Fibrosis and Inflammation in PAH. Antioxidants & Redox Signaling 31:1053-1069, 2019. PMID: 30767565

Kovacs L, Cao Y, Han W, Meadows, L, Kovacs-Kasa A, Kondrikov D, Verin AD, Barman SA, Dong Z, Huo Y, and Su Y. PFKFB3 in Smooth Muscle Promotes Vascular Remodeling in Pulmonary Arterial Hypertension. Am J Resp Crit Care Med 200:617-627, 2019. PMID: 30817168

Cao Y, Zhang X, Wang L, Yang Q, Ma Q, Xu J, Wang J, Kovacs L, Ayon RJ, Liu Z, Zhang M, Zhou Y, Zeng X, Xu Y, Wang Y, Fulton DJ, Weintraub NL, Lucas R, Dong Z, Yuan JX, Sullivan JC, Meadows L, Barman SA, Wu C, Quan J, Hong M, Su Y, Huo Y. PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension. Proc Natl Acad Sci U S.A. 116:13394-13403, 2019. PMID: 31213542