Sangeetha Sukumari Ramesh, PhD

Research Interest, Education & Publications

photo of Sangeetha Sukumari-Ramesh, PhD

Sangeetha Sukumari-Ramesh, PhD

  • Associate Professor
  • Pharmacology & Toxicology

706-446-3645

Carl Sanders Research & Education Building, CB 3618
Office phone icon: 706-446-3645
Lab phone icon: 706-446-3845


Members of the Lab

Noah Watson

  • Graduate Student

Samruddhi Kelkar

  • Research Associate

Kazi Saif

  • Graduate Student
 

RESEARCH INTEREST

Spontaneous intracerebral hemorrhage (ICH) is a stroke subtype associated with high morbidity and mortality. Around 50% of ICH patients die within the first month, and fewer than 20% of survivors regain functional independence. Moreover, the incidence of ICH is expected to grow over the next decades due to population aging and changes in racial demographics. Despite the relatively high incidence rate, there is no effective treatment for ICH, and the efficacy of neurosurgical intervention after ICH remains largely controversial. Lack of effective treatment options, at least in part, reflects on the poorly defined pathophysiology of the detrimental events underlying brain injury after ICH. The long-term goal of my laboratory is to determine the molecular and cellular mechanisms of ICH-induced brain injury and identify novel molecular targets for therapeutic intervention.

 

EDUCATION AND POST-DOCTORAL TRAINING

07/2019    MBA                                                  麻豆官网首页入口

12/2009    Postdoctoral  training                    麻豆官网首页入口                                                           

02/2006    PhD Biochemistry                           Sree Chitra Tirunal Institute for Medical Sciences &Technology, India                                                                                        

07/1999    MS Biochemistry                             Kerala University, India                    

04/1997    B.S. Chemistry                                 Kerala University, India         

 

ACADEMIC/ADMINISTRATIVE APPOINTMENTS

07/2021- Present         Associate Professor, Department of Pharmacology and Toxicology, Medical College of Georgia

EDITORIAL BOARDS

         Editor, Special Issue, "Intracerebral Hemorrhage: Advances in Preclinical Studies鈥�, Biomolecules.

GRANT REVIEW PANELS

American Heart Association

Veteran Affairs-Merit Review Panel

HONORS

Emerging Scientist Award 2019, 麻豆官网首页入口 Research Institute, 麻豆官网首页入口

SELECTED PUBLICATIONS

Dasari R, Zhi W, Bonsack F, Sangeetha Sukumari-Ramesh. A Combined Proteomics and Bioinformatics Approach Reveals Novel Signaling Pathways and Molecular Targets After Intracerebral Hemorrhage. J Mol Neurosci. 2020 Aug;70(8):1186-1197.

Bonsack F and Sukumari-Ramesh S. Differential cellular expression of Galectin-1 and Galectin-3 after Intracerebral Hemorrhage. Front Cell Neurosci. 2019 May 14;13:157

Bonsack F, Foss C, Arbab A, Alleyne CH Jr, Pomper MG, Sukumari-Ramesh S*. [125 I] IodoDPA-713 binding to 18kDa translocator protein (TSPO) in a mouse model of intracerebral hemorrhage: Implications for neuroimaging. Front. Neurosci, 2018 Feb 22;12:66.

Bonsack F, Alleyne CH Jr, Sukumari-Ramesh S. Resveratrol attenuates neurodegeneration and improves neurological outcomes after intracerebral hemorrhage in mice. Front Cell Neurosci. 2017 Aug 8; 11:228.

Bonsack F, Alleyne CH Jr, Sukumari-Ramesh S. Augmented expression of TSPO after intracerebral hemorrhage: a role in inflammation? Journal of Neuroinflammation 2016, Jun 17;13(1):151.

Sukumari-Ramesh S*, Alleyne CH Jr, Dhandapani KM.The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid (SAHA) Confers Acute Neuroprotection After Intracerebral Hemorrhage in Mice. Translational Stroke Research. 2016 Apr; 7(2):141-8. *both first and corresponding author

Sukumari-Ramesh S * and Alleyne CH Jr. Post injury administration of tert-butylhydroquinone attenuates acute neurological injury after Intracerebral hemorrhage in mice. Journal of Molecular Neuroscience, 2016, Apr;58(4):525-31. *both first and corresponding author