Quansheng Du, PhD

Associate Professorqdu

Dept. of Neuroscience & Regenerative Medicine

Mailing Address:

Dept. of Neuroscience & Regenerative Medicine
1120 15 St., Rm. CA3004
Medical College of Georgia at 麻豆官网首页入口
麻豆官网首页入口, GA 30912

E-mail: qdu@augusta.edu
Phone: 706-721-7370
Lab:  Rm. CA3046

Education:

1985-1986  BS in Virology - Dept. of Virology and Molecular Biology, Wuhan University, China
1992-1995  MS in Virology - Inst. of Virology, Wuhan University, China
1995-1998  PhD in Microbiology  -  Inst. of Virology, Wuhan University, China

Training:

1998-1999  Postdoctoral Training, Dept. of Pharmacology, University of Virginia
1999-2005  Postdoctoral Training, Center for Cell Signaling, University of Virginia

Research interests:

  1. Cell division.  We are interested in the molecular mechanisms that regulate mitotic spindle organization and orientation in mammalian system. We are also interested in exploring the role of oriented cell division during epithelial morphogenesis and carcinogenesis.
  2. Cell polarity.  We are interested in how polarity proteins are involved in cell-cell contact formation, cell polarization, cell-cell internalization and epithelial morphogenesis.
  3. Genome organization.  We are interested in the molecular mechanisms underlying cell-cycle-regulated genome organization, focusing on the role of nuclear scaffold proteins.
  4. Stem cell.  We are interested in molecular mechanisms underlying asymmetric cell division of stem cells. We are also interested in how polarity proteins are involved in stem cell fate determination.

 dupics

Selected Publications:

  1. Du Q, Lehavi D, Faktor O, Qi Y, Chejanovsky N.  鈥淚solation of an Apoptosis Suppressor Gene of the Spodoptera littoralis 狈耻肠濒别辞辫辞濒测丑别诲谤辞惫颈谤耻蝉.鈥� Journal of Virology. (1999). 73:1278-85
  2. Du Q, Ren XR, Wang Q, Mei L, Xiong WC.   鈥淚nhibition of PYK2-induced cytoskeletal reorganization, PYK2 autophosphorylation, and focal adhesion targeting by FAK.鈥� Journal of Cell Science, (2001). 114(16): 2977-87
  3. Du Q*, Stukenberg PT, Macara IG.   鈥淎 mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization.鈥� Nature Cell Biology, (2001). 3: 1069-75
  4. Du Q*, Taylor L, Compton DA, Macara IG.   鈥淟GN blocks the ability of NuMA to bind and stabilize microtubules. A mechanism for mitotic spindle assembly regulation.鈥� Current Biology, (2002). 12: 1928-33
  5. Wang Q#, Xie Y#, Du Q#, Wu X, Feng X, Mei L, McDonald JM, Xiong WC 鈥淩egulation of the formation of osteoclastic actin rings by PYK2 interacting with Gelsolin.鈥� Journal of Cell Biology, (2003). 160: 565-75 (# these authors contribute equally to the work).
  6. Du Q, Macara IG.   鈥淢ammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins.鈥� Cell, (2004). 119: 503-16
  7. Sans N, Wang PY, Du Q, Petralia RS, Wang YX, Nakka S, Blumer JB, Macara IG, Wenthold RJ.   鈥渕Pins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression.鈥�&苍产蝉辫; Nature Cell Biology, (2005). 12: 1079-90
  8. Bowman SK, Neum眉ller RA, Novatchkova M, Du Q, Knoblich JA.  鈥淭he Drosophila NuMA Homolog Mud Regulates Spindle Orientation in Asymmetric Cell Division.鈥� Developmental Cell. (2006). 10(6): 731-42
  9. Zhu XJ, Wang CZ, Dai PG, Xie Y, Song N, Liu Y, Du Q, Mei L, Ding YQ, Xiong WC.  鈥淢yosin X regulates netrin receptors and functions in axonal path-finding.鈥� Nature Cell Biology, (2007). 9(2):184-92
  10.  Luo SW, Zhang C, Zhang B, Kim CH, Qiu YZ, Du Q, Mei L, Xiong WC.  "Regulation of heterochromatin remodeling and myogenin expression during muscle differentiation by FAK interaction with MBD2". EMBO J. (2009).  28(17):2568-82
  11. Zheng Z, Zhu H, Wan Q, Liu J, Xiao Z, Siderovski DP, Du Q*.  鈥淟GN regulates spindle orientation during epithelial morphogenesis鈥�, Journal of Cell Biology, (2010). 189: 275-88
  12. Hao Y, Du Q, Chen X, Zheng Z, Balsbaugh JL, Maitra S, Shabanowitz J, Hunt DF, Macara IG.   鈥淧ar3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins鈥�, Current Biology. (2010). 20(20):1809-18
  13. Zhu J, Wen W, Zheng Z, Shang Y, Wei Z, Xiao Z, Pan Z, Du Q*, Wang W*, Zhang M*   鈥淟GN/mInsc and LGN/NuMA Complex Structures Suggest Distinct Functions in Asymmetric Cell Division for the Par3/mInsc/LGN and Gai/LGN/NuMA Pathways鈥�. Molecular Cell, (2011). 43:1-14
  14. Xiao Z, Wan Q, Du Q*, Zheng Z*   鈥淕alpha/LGN-mediated asymmetric spindle positioning does not lead to unequal cleavage of the mother cell in 3-D cultured MDCK cells鈥�. Biochem Biophys Res Commun, (2012) 20;420(4):888-94
  15. Wan Q, Liu J, Zheng Z, Zhu H, Chu X, Dong Z, Huang S, Du Q*   鈥淩egulation of myosin activation during cell-cell contact formation by Par3-Lgl antagonism - Entosis without matrix detachment鈥�.  Molecular Biology of Cell, (2012). 23(11):2076-91, (Highlighted Article)
  16. Zheng Z, Wan Q, Liu J, Zhu H, Chu X, Du Q*.   鈥淓vidence for dynein and astral microtubule-mediated cortical release and transport of G伪i/LGN/NuMA complex in mitotic cells鈥�.  Molecular Biology of Cell, (2013). 24(7):901-13. (Highlighted Article)
  17. Slim CL, Lazaro-Dieguez F, Bijlard M, Toussaint MJ, de Bruin A, Du Q, Muesch A, van Ijzendoorn SC.   鈥淧ar1b Induces Asymmetric Inheritance of Plasma Membrane Domains via LGN-Dependent Mitotic Spindle Orientation in Proliferating Hepatocytes鈥�.  PLoS Biology, (2013). 11(12): e1001739.
  18. Zheng Z#, Wan Q#, Meixiong G#, Du Q*.   鈥淐ell cycle-regulated membrane binding of NuMA contributes to efficient anaphase chromosome separation鈥�. Molecular Biology of Cell, (2014). 25(5):606-19, PMID: 24371089 (# these authors contribute equally to the work)
  19. Zhu J, Shang Y, Wan Q, Xia Y, Chen J, Du Q, Zhang M.  鈥淧hosphorylation-dependent interaction between tumor suppressors Dlg and Lgl鈥�. Cell Research, (2014). 24(4):451-63. PMID: 24513855
  20. Li Y, Wei Z, Yan Y, Wan Q, Du Q, Zhang M.  鈥淪tructure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex鈥�.  Proc. Natl. Acad. Sci. U.S.A., (2014). 111(49):17444.
  21. Chu X, Chen X, Wan Q, Zheng Z, Du Q*.  鈥溾��&苍产蝉辫; Journal of Biological Chemistry. 2016 Jul 26. pii: jbc.M116.724831
  22. Landin Malt A, Dailey Z, Holbrook-Rasmussen J, Zheng Y, Hogan A, Du Q, Lu X.  (2019) Par3 is essential for the establishment of planar cell polarity of inner ear hair cells. Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1816333116. Epub Feb 27.