Ferenc (Frank) Deak, MD, PhD

frank deak

Associate Professor
Dept. of Neuroscience & Regenerative Medicine
Medical College of Georgia

Mailing Address:

Dept. of Neuroscience & Regenerative Medicine
1120 15th Street, Rm. CA4010
Medical College of Georgia at 麻豆官网首页入口
麻豆官网首页入口, GA 30912

E-mail address: fdeak@augusta.edu
phone:  706-721-4624

Education:

1994 Semmelweis Medical University (Budapest, Hungary) - MD

2000 Semmelweis University (Budapest, Hungary) - PhD

Postdoctoral Training:

2008 Post-doctoral fellowship, University of Texas Southwestern Medical School (Dallas, TX, USA)

2012 Associate Consultant, Mayo Clinic (Jacksonville, FL, USA)

Research Interests:

Alzheimer's disease and Memory
Project :  How does Aging effect Synaptic Neurotransmission and contribute to Alzheimer鈥檚 Disease
Title :  Early signs of Alzheimer's Disease caused by dysregulation of Synaptic Neurotransmission.

There are more than 5 million patients in the USA, who suffer from Alzheimer's disease (AD). Cognitive decline in Alzheimer's disease is thought to be the result of disturbed neuronal communication due to synaptic dysfunction. Aggregated amyloid beta protein accumulates in AD, a process leading to impaired neuronal communication. In a series of studies we investigate why aging is the most relevant risk factor to Alzheimer鈥檚 dementia. We test the age-related changes in a set of essential synaptic proteins, which regulate vesicular neurotransmitter release from synapses and their effect on beta-amyloid secretion. Maintaining physiological synaptic function while reducing amyloid secretion may provide a breakthrough to design effective therapies that halt progression of dementia in Alzheimer's disease.

Selected Recent Publications:

  1. .  Raghavendra Y. Nagaraja, David M. Sherry, Jennifer L. Fessler, Megan A. Stiles, Feng Li, Karanpreet Multani, Albert Orock, Mohiuddin Ahmad, Richard S. Brush, Robert E. Anderson, Martin-Paul Agbaga*, Ferenc De谩k*  Mol Neurobiol. 2021 Jul 5. doi: 10.1007/s12035-021-02439-1. Online ahead of print. PMID: 34227061
  2. .  Orock A, Logan S, Deak F.  J Gerontol A Biol Sci Med Sci., 2020 Sep 16;75(9):1624-1632. doi: 10.1093/gerona/glz013  PMID: 30649208.  Editor's Choice - featured in the main periodical of Gerontology Soc. America.
  3.   De谩k F, Anderson RE, Fessler JL, Sherry DM.  Front Cell Neurosci. 2019 Sep 20;13:428. doi: 10.3389/fncel.2019.00428. eCollection 2019. Review.  PMID: 31616255
  4.   Lee YI, Kim YG, Pyeon HJ, Ahn JC, Logan S, Orock A, Joo KM, L艖rincz A, De谩k F. Geroscience. 2019 Apr;41(2):109-123. doi: 10.1007/s11357-019-00067-1. Epub 2019 Apr 30.  PMID: 31041658
  5.   Orock A, Logan S, Deak F.  Mol Cell Neurosci. 2018 Apr;88:33-42. doi: 10.1016/j.mcn.2017.12.002. Epub 2017 Dec 5.  PMID: 29217410
  6.   Hopiavuori BR, De谩k F, Wilkerson JL, Brush RS, Rocha-Hopiavuori NA, Hopiavuori AR, Ozan KG, Sullivan MT, Wren JD, Georgescu C, Szweda L, Awasthi V, Towner R, Sherry DM, Anderson RE, Agbaga MP.  Mol Neurobiol. 2018 Feb;55(2):1795-1813. doi: 10.1007/s12035-017-0824-8. Epub 2017 Nov 22.  PMID: 29168048
  7.   Tucsek Z, Noa Valcarcel-Ares M, Tarantini S, Yabluchanskiy A, F眉l枚p G, Gautam T, Orock A, Csiszar A, Deak F, Ungvari Z.  Geroscience. 2017 Aug;39(4):385-406. doi: 10.1007/s11357-017-9981-y. Epub 2017 Jun 29.  PMID:  28664509
  8. Memory loss: Five new things.  Deak et al. Neurol Clin Pract. 2016 Dec;6(6):523-529. doi: 10.1212/CPJ.0000000000000314.  Memory loss can be due to a wide variety of causes. We provide new information about the biology of common genetic and acquired causes of memory loss in older adults.
  9.   Deak F, Freeman WM, Ungvari Z, Csiszar A, Sonntag WE. J Gerontol A Biol Sci Med Sci. 2016 Jan;71(1):13-20. doi: 10.1093/gerona/glv206. Epub 2015 Nov 20. Review.  PMID: 26590911
  10. Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease.  Liu et al. Neuron. 2014 Oct 1;84(1):63-77. doi: 10.1016/j.neuron.2014.08.048.

 

Open Positions in the Deak Lab:

  1. We support the training of graduate students, and accept applications for laboratory rotation.
  2. We encourage interested electrophysiology experts to apply for a post-doctoral fellowship in our laboratory  -  Job Opening ID: 247302
  3.  We have Current open position for Research Assistant  -  Job Opening ID: 247305

 

Apply at: 

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