鈥淐ircadian origins of vascular disease in obesity鈥�
Studies will determine how the disruption in circadian rhythm impairs the cardiovascular
function in obesity.
鈥淐ircadian Clock Control of Endothelial Identity in Atherosclerosis鈥�
Our overarching hypothesis is that circadian rhythmicity is important to maintain
endothelial homeostasis via Sox17 expression and that perturbation of rhythms corrupts
endothelial function and encourages the development of atherosclerosis.
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt.
Fulton D., Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos
A, Sessa WC. Nature. 1999 Jun 10;399(6736):597-601.
Glucose wears down circadian clocks in obesity, may drive cardiovascular risk