The Hong Laboratory
Bangxing Hong, PhD
Assistant Professor, Department of Pathology
Georgia Cancer Center
Medical College of Georgia at 麻豆官网首页入口
Jump to: Research Summary Research Interests Selected Publications Research Team
Contact Us
The Bangxing Hong Lab
Health Sciences Campus
1410 Laney Walker Blvd., CN-3205L1
(706) 721-1187
Research Summary
The Hong laboratory is interested in developing novel immunotherapy through modulation of antigen presentation activity of dendritic cells, generation of antigen specific T cell-based cell therapy or developing oncolytic virus-based immunotherapy to target incurable tumor including glioblastoma, lymphoma, and other solid tumors.
Research Interests
State of the art technologies including CyTOF, scRNA-seq and proteomics are been used in our study. Ongoing projects include:
Oncolytic Virotherapy:
Oncolytic virotherapy is an emerging novel treatment for cancer patients. HSV-1-based oncolytic virus has been approved for metastatic cancer and relapse glioblastoma treatment. We are developing HSV-1 based oncolytic virus that disabling tumor-intrinsic and tumor-extrinsic factors that limit oncolytic virus infection, replication, and induction of anti-tumor immune response (JITC 2025; Molecular Cancer Therapeutics 2024; JITC鈥�2023;鈥�Clinical Cancer Research鈥�2021).鈥赌�
Modulation Antigen Presentation for Immunotherapy:
Through modulation the activities of antigen presentation attenuators (APAs), such as SOCS1 and A20, in antigen presentation cells (dendritic cells), we can reverse the tolerization of dendritic cells and generation of strong adaptive immune response again cancer (JITC 2023; Cancer Research 2009) or HIV(JCI 2011).
T cell Immunotherapy:
We develop antigen specific T cells including cytotoxic T lymphocytes (CTLs), Th9 or Tc9 cells to induce strong anti-tumor immune response against solid tumor through modulation of immune suppressive signaling in tumor microenvironment (Gene Therapy 2012; PNAS2014; JCI2011; JCI2012).
Selected Publications
- Tsuboi N, Rivera-Caraballo KA, Sahu U, Pacholczyk R, Douglass E, Johnson TS, Wang Q, Kolhe R, Hedrick CC, Munn DH, Hong B*. Blocking feedback immunosuppression of antigen presentation in brain tumor during oncolytic virotherapy with oHSV-mshPKR. Molecular Cancer Therapeutics, 2024, doi:10.1158/1535-7163. (* Corresponding author)
- Kyritsi K, Pacholczyk R, Douglass E, Yu M, Fang H, Zhou G, Kaur B, Wang Q, Munn DH, Hong B*. b-blocker suppresses both tumoral sympathetic neurons and perivascular macrophages during oncolytic herpes virotherapy. The Journal for Immunotherapy of Cancer, 2025, In press. (* Corresponding author)
Additional Publications
| Publication |
|---|
Kyritsi, K., , Douglass, E., Yu, M., Fang, H., , , , & , Apr 5 2025, In: Journal for ImmunoTherapy of Cancer. 13, 4, e011322. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Tsuboi, N., Rivera-Caraballo, K. A., Sahu, U., , Douglass, E., , , , , & , Mar 1 2025, In: Molecular cancer therapeutics. 24, 3, p. 444-452 9 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Kyritsi, K., Ye, J., Douglass, E., , Tsuboi, N., Otani, Y., , , & , Jan 1 2025, In: Neuro-Oncology Advances. 7, 1, vdaf080. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Qin, A., Shi, K., Tindall, R. R., Li, J., Cheng, B., Li, J., Yang, B., Yu, Q., Zhang, Y., , , Younes, M., Shen, Q., Bailey-Lundberg, J. M., Cao, Y. & Ko, T. C., Jan 2025, In: Gastro Hep Advances. 4, 2, 100557. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Sahu, U., Mullarkey, M. P., Pei, G., Zhao, Z., & , Jun 15 2023, In: Molecular Therapy Oncolytics. 29, p. 30-41 12 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Swanner, J., Shim, J. S., Rivera-Caraballo, K. A., V谩zquez-Arregu铆n, K., , Bueso-Perez, A. J., Lee, T. J., Banasavadi-Siddegowda, Y. K., & Yoo, J. Y., Mar 16 2023, In: Molecular Therapy Oncolytics. 28, p. 171-181 11 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
, Sahu, U., Mullarkey, M. P., Hong, E., Pei, G., Yan, Y., Otani, Y., Banasavadi-Siddegowda, Y., Fan, H., Zhao, Z., Yu, J., Caligiuri, M. A. & , Feb 16 2023, In: Journal for ImmunoTherapy of Cancer. 11, 2, e006164. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Arunachalam, E., Rogers, W., Simpson, G. R., M枚ller-Levet, C., Bolton, G., Ismael, M., Smith, C., Keegen, K., Bagwan, I., Brend, T., Short, S. C., , Otani, Y., , Annels, N., Morgan, R. & Pandha, H., Dec 2022, In: BMC Cancer. 22, 1, 400. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Otani, Y., Yoo, J. Y., Lewis, C. T., Chao, S., Swanner, J., Shimizu, T., Kang, J. M., Murphy, S. A., Rivera-Caraballo, K., , Glorioso, J. C., Nakashima, H., Lawler, S. E., Banasavadi-Siddegowda, Y., Heiss, J. D., Yan, Y., Pei, G., Caligiuri, M. A., Zhao, Z. & Antonio Chiocca, E. & 2 others, , Apr 1 2022, In: Clinical Cancer Research. 28, 7, p. 1460-1473 14 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
, Sahu, U., Mullarkey, M. P. & , Jan 2022, In: Viruses. 14, 1, 118. Research output: Contribution to journal 鈥� Review article 鈥� peer-review |
, Chapa, V., Saini, U., Modgil, P., Cohn, D. E., He, G., Siddik, Z. H., Sood, A. K., Yan, Y., Selvendiran, K., Pei, G., Zhao, Z., Yoo, J. Y. & , Jan 15 2021, In: Clinical Cancer Research. 27, 2, p. 542-553 12 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Yoo, J. Y., Swanner, J., Otani, Y., Nair, M., Park, F., Banasavadi-Siddegowda, Y., Liu, J., Jaime-Ramirez, A. C., , Geng, F., Guo, D., Bystry, D., Phelphs, M., Quadri, H., Lee, T. J. & , Sep 6 2019, In: Neuro-Oncology. 21, 9, p. 1131-1140 10 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
, Muili, K., Bolyard, C., Russell, L., Lee, T. J., Banasavadi-Siddegowda, Y., Yoo, J. Y., Yan, Y., Ballester, L. Y., Bockhorst, K. H. & , Mar 29 2019, In: Molecular Therapy Oncolytics. 12, p. 93-102 10 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Russell, L., Swanner, J., Jaime-Ramirez, A. C., Wang, Y., Sprague, A., Banasavadi-Siddegowda, Y., Yoo, J. Y., Sizemore, G. M., Kladney, R., Zhang, J., Lehman, N. L., Ostrowski, M. C., , Caligiuri, M., Yu, J. & , Dec 1 2018, In: Nature communications. 9, 1, 5006. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Wang, D., Huang, X. F., , Song, X. T., Hu, L., Jiang, M., Zhang, B., Ning, H., Li, Y., Xu, C., Lou, X., Li, B., Yu, Z., Hu, J., Chen, J., Yang, F., Gao, H., Ding, G., Liao, L. & Rollins, L. & 3 others, , Feb 8 2018, In: JCI Insight. 3, 3 Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Dang, R. J., Yang, Y. M., Zhang, L., Cui, D. C., , Li, P., Lin, Q., Wang, Y., Wang, Q. Y., Xiao, F., Mao, N., Wang, C., Jiang, X. X. & Wen, N., Aug 1 2016, In: Journal of Cellular and Molecular Medicine. 20, 8, p. 1550-1560 11 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Huang, X. F., Nandakumar, V., Tumurkhuu, G., Wang, T., Jiang, X., , Jones, L., Won, H., Yoshii, H., Ozato, K., Masumi, A. & Chen, S. Y., 2016, In: Cell Death and Disease. 7, 6, e2260. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
, Li, H., Zhang, M., Xu, J., Lu, Y., Zheng, Y., Qian, J., Chang, J. T., Yang, J. & Yi, Q., Jan 1 2015, In: International Journal of Cancer. 136, 1, p. 34-43 10 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Zhang, M., Qian, J., Lan, Y., Lu, Y., Li, H., , Zheng, Y., He, J., Yang, J. & Yi, Q., Sep 1 2014, In: International Journal of Cancer. 135, 5, p. 1132-1141 10 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Park, J., Li, H., Zhang, M., Lu, Y., , Zheng, Y., He, J., Yang, J., Qian, J. & Yi, Q., Aug 2014, In: Cancer Immunology, Immunotherapy. 63, 8, p. 835-845 11 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Lu, Y., Zhang, M., Wang, S., , Wang, Z., Li, H., Zheng, Y., Yang, J., Davis, R. E., Qian, J., Hou, J. & Yi, Q., Jun 24 2014, In: Nature communications. 5, 4229. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
, Li, H., Lu, Y., Zhang, M., Zheng, Y., Qian, J. & Yi, Q., May 31 2014, In: Molecular cancer. 13, 1, 132. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Lu, Y., , Li, H., Zheng, Y., Zhang, M., Wang, S., Qian, J. & Yi, Q., Feb 11 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 6, p. 2265-2270 6 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Liu, Z., Xu, J., Li, H., Zheng, Y., He, J., Liu, H., Zhong, Y., Lu, Y., , Zhang, M., Lin, P., Du, J., Hou, J., Qian, J., Kwak, L. W., Yi, Q. & Yang, J., Dec 10 2013, In: PloS one. 8, 12, e82453. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
He, J., Liu, Z., Zheng, Y., Qian, J., Li, H., Lu, Y., Xu, J., , Zhang, M., Lin, P., Cai, Z., Orlowski, R. Z., Kwak, L. W., Yi, Q. & Yang, J., Dec 15 2012, In: Cancer Research. 72, 24, p. 6393-6402 10 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Wang, L., , Jiang, X., Jones, L., Chen, S. Y. & Huang, X. F., Nov 7 2012, In: PloS one. 7, 11, e48930. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
, Lee, S. H., Song, X. T., Jones, L., Machida, K., Huang, X. F. & Chen, S. Y., Nov 7 2012, In: PloS one. 7, 11, e48614. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Lu, Y., Hong, S., Li, H., Park, J., , Wang, L., Zheng, Y., Liu, Z., Xu, J., He, J., Yang, J., Qian, J. & Yi, Q., Nov 1 2012, In: Journal of Clinical Investigation. 122, 11, p. 4160-4171 12 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
, Peng, G., Berry, L., Gottschalk, S., Jung, J. U., Chen, S. Y. & Huang, X. F., Aug 2012, In: Gene Therapy. 19, 8, p. 818-827 10 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
, Song, X. T., Rollins, L., Berry, L., Huang, X. F. & Chen, S. Y., Feb 1 2011, In: Journal of Clinical Investigation. 121, 2, p. 739-751 13 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Song, X. T., Turnis, M. E., Zhou, X., Zhu, W., , Rollins, L., Rabinovich, B., Chen, S. Y., Rooney, C. M. & Gottschalk, S., Jan 2011, In: Molecular Therapy. 19, 1, p. 211-217 7 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
, Ren, W., Song, X. T., Evel-Kabler, K., Chen, S. Y. & Huang, X. F., Oct 15 2009, In: Cancer Research. 69, 20, p. 8076-8084 9 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
Lee, S. H., , Sharabi, A., Huang, X. F. & Chen, S. Y., Jul 2009, In: Stem Cells. 27, 7, p. 1604-1615 12 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
, Jiang, L. F., Hu, Y. S., Fang, D. Y. & Guo, H. Y., Sep 2004, In: Journal of Microbiological Methods. 58, 3, p. 403-411 9 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
, Jiang, L. F., Hu, Y. S., Fang, D. Y. & Guo, H. Y., Mar 2004, In: Chinese Journal of Microbiology and Immunology. 24, 3, p. 241-244 4 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
, Jiang, L. & Zhang, X., Sep 2000, In: Chinese Journal of Microbiology and Immunology. 20, 5, p. 477-480 4 p. Research output: Contribution to journal 鈥� Article 鈥� peer-review |
.
Research Team
Konstantina Kyritsi, PhD
- Postdoctoral Fellow