The Kaur Lab
Balveen Kaur, PhD
Associate Director Research, Georgia Cancer Center
Professor, Pathology
Medical College of Georgia at 麻豆官网首页入口
Our Research
The Kaur laboratory is a drug development laboratory that specializes in biotherapies to combat cancer.
We design oncolytic viruses which are engineered to destroy cancer cells with a precision that only biologics can have. Currently there are three oncolytic viruses that are approved for treatment in the world. These viruses then also fine tune the body鈥檚 immune system to seek and clear residual neoplastic cells. Our research is funded by the NIH, DOD, and American Society for Cell and Gene Therapy. We use state of the art technology to uncover the molecular proteomic and metabolic underpinnings of cancer cell and virus interactions.
Contact Us
The Kaur Lab
Health Sciences Campus
1410 Laney Walker, Blvd
CN-3205Q1
706-721-8415
Research Summary
Uncovering host barriers to oncolytic viral therapy:
This is a large multi-institutional program project funded through the NCI. Through this project we are uncovering resistance mechanisms to virus therapy. In this collaborative grant we utilize lessons learnt from an ongoing clinical trial to advance next gen treatment strategies.
Designing Second Generation Therapeutics:
We are evaluating how treated tumor cells change the signaling in the tumor microenvironment. Our recent research published on the cover of Clinical Cancer Research has uncovered changes in cell-to-cell interaction that provides novel avenues for the design of second generation therapeutics. We have used this information to develop a novel virus that can fight cancer by affecting both the cancer cells and the stroma. This project is funded through an NINDS R61/R35 bio therapeutic drug development grant.
Novel Murine models for Virotherapy:
Viruses have evolved to be extremely species specific which makes the preclinical evaluation of these agents very challenging. The Kaur laboratory is developing next generation transgenic mice models that are sensitive to the cold sore virus to better reflect efficacy and toxicity of this therapeutic strategy.
Antibody Targeted Therapy
We are also engaged in harnessing the potential of antibodies to target solid tumors. Strategies being explored include advanced ways of drug delivery to counter blood brain tumor barriers. This project is funded by an ongoing DOD grant, and a collaborative multi institutional R01 grant.
Uncovering impact of Novel therapies on tumor microenvironment:
Through this project we dissect the impact of tumor induced signaling changes on non cancerous cells in the tumor microenvironment. Dr Arreguin is funded through a mentored American Society for Gene and Cell therapy grant for this project. We also have a large NIH funded R01 that is investigating the impact of tumor specific blockade of cancer stem cell like signaling.
Selected Publications
Hong BH, Sahu U, Mullarkey MP, Hong E, Pei G, Yan Y, Otani Y, Banasavadi-Siddegowda
Y, Fan H, Zhao Z, Yu J, Caligiuri MA, Kaur B. Journal for Immunotherapy of Cancer. (2023) Feb;11(2):e006164. doi: 10.1136/jitc-2022-006164.
Tian T, Xu B, Chen Y, Li Z, Wang J, Zhang J, Ma R, Cao S, Hu W, Chiocca EA, Kaur B, Caligiuri MA, Yu J. Nature Cancer (2022) Nov;3(11):1318-1335.
Anami Y, Otani Y, Xiong W, Ha SYY, Yamaguchi A, Rivera-Caraballo K, Zhang N, An Zhiqiang, Kaur B, Tsuchikama K. Cell reports (2022) 39(8):110839.
Otani Y, Dr. Yoo JY, Lewis CT, Chao S, Swanner J, Shimizu T, Kang JM, Murphy SA, Rivera Caraballo KA, Hong B, Glorioso JC, Nakashima H, Lawler SE, Banasavadi-Siddegowda YK, Heiss JD, Yan Y, Pei G, Caliguri MA, Zhao Z, Chiocca EA, Yu J, Kaur B. Clinical Cancer research (2022) Apr 1;28(7):1460-1473.
Xu B, Tian L, Chen J, Wang J, Ma R, Dong W, Li A, Zhang J, Chiocca EA, Kaur B, Feng M, Caligiuri M, and Yu J. (2021) Nature Communications Oct 8;12(1):5908.
Otani Y, Sur H, Rachaiah G, Namagiri S, Chowdhury A, Lewis CT, Shimizu T, Gangaplara A, Wang X, V茅zina A, Maric D, Jackson S, Yan Y, Zhengping Z, Ray-Chaudhury A, Kumar S, Ballester LY, Chittiboina P, Yoo JY, Heiss J, Kaur B, Kumar Banasavadi-Siddegowda y. Neuro Oncol. 2021 Sep 1;23(9):1481-1493.
Hong B, Chapa V, Saini U, Modgil P, Cohn DE, He G, Siddik ZH, Sood AK, Yan Y, Karuppaiyah S, Pei G, Zhao Z, Yoo JY, Kaur B. (2021) Can. Res. 27:2:542-553.
Otani Y, Yoo JY, Chao S, Liu J, Jaime-Ramirez AC, Lee TJ, Hurwitz B, Yan Y, Dai H, Glorioso JC, Caligiuri MA, Yu J, Yan y and Kaur B. Clinical Cancer Research (2020) May 15;26(10):2381-2392.
Yoo JY, Swanner J, Otani Y, Nair M, Park F, Banasavadi-Siddegowda Y, Liu J, Jaime-Ramirez CA, Hong B, Geng F, Guo D, Bystry D, Phelps M, Quadri H, Lee TJ, Kaur B. Neuro-Oncology (2019), Vol.21 (9), p.1131-1140
Russell L, Swanner J, Jaime-Ramirez CA, Wang Y, Sprague A, Banasavadi-Siddegowda Y, Yoo JY, Sizemore GM, Kladney R, Zhang J, Lehman NL, Ostrowski M, Hong B, Caligiuri M, Yu J, Kaur B. Nature Communications. (2018). 9(1):5006. doi: 10.1038/s41467-018-07344-1.
Xu B, Ma R, Russell L, Yoo JY, Han J, Cui H, Yi P, Zhang J, Nakashima H, Dai H, Chiocca EA, Kaur B, Caligiuri M, Yu J. Nature Biotechnology (2019) doi: 10.1038/nbt.4302. 37(1) 45-54.
Banasavadi-Siddegowda YK, Welker AM, An M, Yang X, Zhou W, Shi G, Imitola J, Li C, Hsu S, Wang J, Phelps M, Zhang J, Beattie CE, Baiocchi R, Kaur B. (2018) Neuro-Oncology. 20(6): 753-763.
Kim Y, Yoo JY, Lee TJ, Liu J, Yu J, Caligiuri M, Kaur B*, Friedman A*. Natl. Acad Sci. USA. (2018,). 15(19):4927-4932.
Research Team
Adam Chadli
I am a Research Associate in the Kaur lab. Working as a lab manager and helping in the research.
Fun facts: I have two cutie daughters. My daughters are the strength/power of my life; I enjoy my every moment with them.
I am a 5th-year PhD candidate working on immunomodulation of the tumor microenvironment with oHSV therapy.
Fun fact: I have lived on all 3 coasts of the contiguous United States.
I am a post-doctoral fellow in the Kaur Lab. My research focuses on identifying major resistance pathways and tumor extracellular matrix factors leading to therapy resistance with a specific focus on understanding the regulation of glioma cell stemness and metabolism as drivers of pathology using oHSVs.
Fun fact: I speak 3 languages and I belong to a place with the longest dam in the world.
I am a post-doctoral fellow in Dr. Kaur鈥檚 lab. I work on designing and checking the efficacy of antibodies that can cross the blood brain barrier in metastatic brain tumors.
Fun fact: My son and I were born on the same day... just years apart.
Harmanpreet Singh
I am a post-doctoral fellow in the Kaur laboratory, with a research focus on developing new oHSVs that disrupt the communication between GBM cancer cells and the tumor microenvironment, therefore allowing for better targeting of GBM tumors.
Fun fact: I was born and raised in central M茅xico.